Dexamethasone has been associated with significant reduction in mortality rates of patients requiring supplemental oxygen r1.Several antiviral medications are available, including remdesivir, ritonavir-boosted nirmatrelvir, and molnupiravir.Treatments and treatment strategies continue to be refined available drugs are administered at different stages of disease based on the pharmacologic mechanism of action and the dominant pathophysiology of the disease phase.Diagnosis is confirmed by detection of viral RNA on polymerase chain reaction test of upper or lower respiratory tract specimens antigen testing is also available and has near-equivalent specificity but is slightly less sensitive.Chest imaging in symptomatic patients almost always shows abnormal findings, usually including bilateral infiltrates laboratory findings are variable but typically include lymphopenia and elevated lactate dehydrogenase and transaminase levels. Infection should be suspected based on presentation with a clinically compatible history (eg, fever, upper or lower respiratory tract symptoms) alterations in senses of smell and taste are particularly suggestive. Disease may evolve over the course of a week or more from mild to severe deterioration may be sudden and catastrophic
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